Prior to starting a supplementation routine with milk thistle, discuss the safety and dosage requirements with your physician. Milk thistle or silymarin comes from the seeds of the plant it is named for and gets its name from the milky sap that comes out of the plant's leaves when they are broken. What is the Difference Between Blended Learning & Distance Learning? Summary: Drug interactions are reported among people who take Lisinopril and Milk thistle. Should Colleges Be Allowed to Enforce Mandatory Drug Tests? Life Brand Milk Thistle is standardized to 80% silymarin in a base of dandelion and turmeric, two botanicals that, combined with milk thistle, help maintain liver health. The aim of the present study was to determine the effect of a standardized milk thistle supplement on major P450 drug-metabolizing enzymes after a 14-day exposure period. Although milk thistle has been historically used to enhance fertility and improve the flow of breast milk, as there is not enough reliable medical research about safety. He or she should monitor your blood pressure carefully, and adjust the dosage of one or both medications … Other Miscellaneous Uses - People report taking milk thistle to help improve appetite, heartburn, gallbladder complaints, bad breath, cough, and infertility. The National Diabetes Information Clearinghouse reports high blood sugar contributes to high blood pressure. Terms of Use ; April 2011, National Diabetes Information Clearinghouse; Prevent Diabetes Problems: Keep Your Heart and Blood Vessels Healthy; April 2009, Mayo Clinic; Milk Thistle (Silybum marianum) Safety; April 2011, Mayo Clinic; Milk Thistle (Silybum marianum) Evidence; April 2011, University of Maryland Medical Center; Milk Thistle; Steven D. Ehrlich, N.M.D. Cancer - Some early studies suggest that milk thistle may stop cancer cells from dividing and reduce blood supply to tumors. Share on Pinterest. Taking milk thistle might decrease how well the body breaks down raloxifene (Evista) in the intestines. Quiz & Worksheet - Milk Thistle Interactions & Contraindications, Over 83,000 lessons in all major subjects, {{courseNav.course.mDynamicIntFields.lessonCount}}, What is Medicinal Herbology? Milk, Soy Milk, Milk-Based Smoothies Calcium can interfere with the effectiveness of thyroid medication. Many of those uses are based on tradition or untested theories. Taking milk thistle might affect this enzyme and drugs it processes, such as diazepam (Valium), warfarin (Coumadin, Jantoven) and others. Taking milk thistle along with diabetes medications might cause your blood sugar to be too low. An in vitro study has shown that Milk Thistle had interactions with several drugs, particularly some HIV drugs, due to it blocking an enzyme in the liver which controls a detoxification pathway. The interaction between milk thistle and pyrazinamide is based on experimental evidence only. This can cause excess sedation, a lowering of blood pressure, physical depression, suppression of the lungs and cognitive impairment. Milk Thistle is used to treat alcoholic liver disease, gallbladder problems, hepatic cirrhosis, hepatitis (), hepatotoxicity (chemical/drug-induced), jaundice, pleurisy, prostate cancer, and spleen diseases, and used as an appetite stimulant.. The result is high-than-normal levels of those drugs in the body. High blood pressure occurs when the artery wall pressure rises above 120 systolic and 90 diastolic, which is measured in millimeters of mercury. Silymarin, a chemical found in milk thistle, can decrease blood sugar levels. Herb-Drug Interactions: Milk thistle April 19, 2011 Herbalist Off Milk thistle, Contents. Milk thistle is often promoted for its liver … and - Definition, Causes, Symptoms & Treatment, What Is Encopresis? Closely monitor your blood sugar levels. However, there is the potential for many drug interactions, especially with medications broken down by cytochrome P-450 3A4 and UGT (Uridine 5'-diphospho-glucuronosyltransferase) substrates. Milk thistle compounds significantly improved markers for type 2 diabetes over placebo and over baseline measurements in patients. Sciences, Culinary Arts and Personal Jonathan McLelland has been a professional writer since 2005. No matter how it is consumed, the recommended dosage ranges from 280 to 450 mg per day. Take milk thistle in capsule, extract or infusion form. The HCV Advocate says that the lipid-lowering drugs Lescol, Mevacor, Pravachol, Zocor and Baycol all have the potential to interact with milk thistle in this way. Log in or sign up to add this lesson to a Custom Course. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. study This could increase the effects and side effects of raloxifene (Evista). If milk thistle is taken by someone using protease inhibitors or non-nukes, it has the potential to raise levels of these drugs, causing unpleasant or even dangerous side effects. He has worked as a story writer and editor for the international sitcom, “Completing Kaden,” as well as a proposal writer for various production companies. A salesperson approaches you and asks if they can interest you in an herbal medicine that can be used to treat many illnesses from liver disease to mushroom poisoning and can even be sprinkled on your salad! used as a substitute for professional medical advice, Below is a short list of some other medications that are processed through the CYP3A4 enzyme. Copyright Policy In some cases, the concentrations may increase (increasing the risk of side effects) and, in others, drop (decreasing the effectiveness of the drug). Metronidazole (Flagyl). Enrolling in a course lets you earn progress by passing quizzes and exams. just create an account. This lesson will discuss the herb milk thistle and its uses as a medicinal plant. It should not be Moreover, we do not select every advertiser or advertisement that appears on the web site-many of the It also seems to have blood sugar-lowering, antioxidant, and anti-inflammatory effects. Milk Thistle Interactions With Blood Pressure Drugs Smell Your Does Make Urine both types of liver failure have similar symptoms which we’ll address here. Get the unbiased info you need to find the right school. - Definition, Types, Requirements & Risks, What is Chronic Gastritis? - Causes, Symptoms & Treatment, What Is Dumping Syndrome? Pregnancy or breastfeeding. If gone unchecked, high blood pressure may damage the kidneys, blood vessels and the heart. These liver problems include cirrhosis, jaundice, hepatitis, an The prescribing information for one prescription medication, Olysio™ (simeprevir), specifically mentions that it should not be taken with milk thistle, due to the risk of milk thistle increasing blood levels of Olysio. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. When taking Invokana with a high blood pressure medication, your blood pressure may become too low. Answered by Dr. Anne Larson: No Interaction: These medicines do not interact with Milk Thistle… This document does not contain all possible interactions. Diabetes because milk thistle can lower blood sugar and may affect dosing of other blood sugar medications. 's' : ''}}. The milk thistle I have is 1000mg. Milk thistle should not be used in place of medication prescribed for you by your doctor. Earn Transferable Credit & Get your Degree. If milk thistle is taken by someone using protease inhibitors or non-nukes, it has the potential to raise levels of these drugs, causing unpleasant or even dangerous side effects. It is also used as a diuretic for increasing urine output, and for promoting the flow of breast milk in new mothers. USES: Milk thistle has been used for diabetes in combination with standard treatment. 30 July 2001.Related: PK and drug interactions. All rights reserved. Published February 24 2014. Some people also call it Mary thistle and holy thistle. Milk thistle can change the way that your body metabolizes certain drugs in the liver, triggering interactions with: Milk thistle shouldn't be taken by people with certain conditions, such as allergies to plants in the same family, pregnancy or breastfeeding, a history of hormone-related cancers and conditions, and diabetes. Milk Thistle (Silybum Marianum) Many drugs and environmental toxins are processed through the liver. It is both an anti-inflammatory and antioxidant. Milk thistle may also help patients with Hepatitis C. Mushroom Poisoning -Animal studies have found that milk thistle counteracts toxic effects of the ''death cap'' mushroom (. and career path that can help you find the school that's right for you. But, there are also drugs that this herb interacts with that you must be aware of prior to taking it, as well as safety concerns and contraindications (conditions or factors influencing the decision to withhold this treatment due to potential harm). But before you take some, you decide to do some research on the interactions it may have with some of the medications you are currently taking. ConsumerLab.com's answer explains. courses that prepare you to earn Diabetes medications are also used to lower blood sugar. When taking Invokana with a high blood pressure medication, your blood pressure may become too low. If you take any prescription medications, check with your healthcare provider before taking milk thistle. ; March 2009, PARTNER & LICENSEE OF THE LIVESTRONG FOUNDATION. Interactions overview In vitro studies have suggested that milk thistle may interact with a number of drugs by inhibiting their metabolism by various cytochrome P450 isoenzymes or affecting their transport by P-glycoprotein. M Kwon et al., “Organic cation transporter-mediated drug-drug interaction potential between berberine and metformin”, Arch Pharm Res. {{courseNav.course.topics.length}} chapters | MayoClinic.com states animal and laboratory research found milk thistle may be capable of lowering high cholesterol levels; however, further research is necessary to determine its true effectiveness. Examples of these drugs are some immunosuppressants, chemotherapeutic drugs, antifungals, antibiotics, many antidepressants and antianxiety drugs, blood thinners, allergy medications (such as Allegra), cholesterol medications, birth control, and caffeine. Log in here for access. You can test out of the do these drugs interact with milk thistle?" Milk thistle may reduce your blood sugar, so it needs to be used with caution as it may trigger hypoglycemia (low blood sugar) in people on diabetes medications. Milk thistle (Silybum marianum) has been used for thousands of years for gallbladder and liver conditions.The flavonoid complex Silymarin is the main active ingredient in the dried fruit of the milk thistle. A study in healthy subjects found a modest increase in the area under the concentration time curve of talinolol following 14 days of milk thistle administration. HTB. * MILK THISTLE. Milk thistle may interfere with many medications and increase them to dangerous levels because the same liver enzymes break down the herb. Basically will there be any bad side effects if I take blood pressure meds like atenolol and norvasc with milk thistle of course at different times. However decreasing your dog’s exposure to toxic drugs plants chemicals and other substances will help to protect him from it. ... No Interaction: These medicines do not interact with Milk Thistle. Medical Disclaimer: The information on this site is for your information only and is not a substitute for professional medical advice, To unlock this lesson you must be a Study.com Member. Cytochrome P450 2C9 (CYP2C9) substrates. Milk thistle, as an inhibitor of this enzyme, blocks it from working as well and prevents or slows how well it can break down certain drugs. Many meds for people with AIDS, for example, are processed by this liver enzyme. Select a subject to preview related courses: In doing your research into the safety of milk thistle you learn that the U.S. Food and Drug Administration (FDA) does not strictly regulate herbs and supplements. Milk thistle may interfere with many medications and increase them to dangerous levels because the same liver enzymes break down the herb. The National Heart Lung and Blood Institute reports nearly one in three adults within American has high blood pressure. You think it might be helpful for your gallbladder issues. 10-19: Anaemia (lack of blood) Gastrointestinal haemorrhage (bleeding gastrointestinal tract) It is important to consume a milk thistle supplement with a 70 to 80 percent silymarin concentration. "what do you suggest if my father takes lamivudine and tenofovir for his liver. Top answers from doctors ... Certain blood pressure medications can cause dangerous rebound effects if … "what do you suggest if my father takes lamivudine and tenofovir for his liver. Blood pressure is defined as the pressure pushed against artery walls as a result of the heart pumping blood. Some cellular studies found that milk thistle may affect CYP enzymes in the liver that metabolize drugs; human studies suggest this effect is minor, but interactions are possible [ 29 ]. Milk thistle may interact with other drugs. Herbal Health Technician: Profile of a Career in Herb Medicine. Food- Milk thistle leaves and flowers can be used in salads as a substitute for vegetables or greens like spinach. Blood pressure is defined as the pressure pushed against artery walls as a result of the heart pumping blood. Re: Milk Thistle Interactions with Blood Pressure Drugs? Ask doctors free. If milk thistle is taken by someone using protease inhibitors or non-nukes, it has the potential to raise levels of these drugs, causing unpleasant or even dangerous side effects. Because schisandra is also metabolized by the liver, it can alter drug concentrations in the body. You also discover that there are certain conditions that might be absolute contraindications to milk thistle due to the potential for harmful interactions. Milk thistle has been used to treat disorders of the liver and gallbladder for at least 2,000 years. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your healthcare provider before taking Invokana with a blood pressure medication. This compound is actually comprised of three chemicals, known as silicristin, silibinin and silidianin. The LIVESTRONG Foundation and LIVESTRONG.COM do not endorse The seeds of the milk thistle plant are commonly used to protect the liver from damage caused by hepatitis viruses as well as alcohol and other substances. However, because so little information is available, it is not known which medications might interact with milk thistle or how exactly to handle these interactions. Those who took silymarin also showed some weight loss and reduced diastolic blood pressure , but these effects were not significant. The University of Maryland Medical Center reports milk thistle is available in liquid extract, standardized dried extract in capsule form as well as a tincture. - Definition & Types, Valerian Root: Side Effects & Drug Interactions, Ajuga Parviflora: Medicinal Uses & Chemical Constituents, Ajuga Reptans: Varieties & their Medicinal Uses, Milk Thistle: Dosage, Side Effects & Overdose Symptoms, Biological and Biomedical Milk thistle can increase levels of some drugs and can also lower those levels. However, in vivo studies suggest that any such inhibition is unlikely to be clinically relevant. Supplements should contain 70 to 80 percent silymarin, which is what’s extracted from the seeds. Take milk thistle in capsule, extract or infusion form. The University of Maryland Medical Center states this herb should never be taken alongside antipsychotics, allergy medications, anti-anxiety drugs and high cholesterol medications. The University of Maryland Medical Center reports these compounds are responsible for enhancing liver cell reproduction, and protecting new liver cells from damage. Many herbs and supplements may also interact with milk thistle and lead to unfavorable side effects. Wait at least 4 hours after dosage to drink any calcium-rich beverages. The study is created by eHealthMe based on reports of 236 people who take Lisinopril and Milk thistle from the FDA, and is updated regularly. 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Pharmacokinetic parameters were calculated by non-compartmental methods, and the potential interaction by silymarin was handled as an equivalence problem. LIVESTRONG is a registered trademark of the LIVESTRONG Foundation. However, determining the potential for clinically significant drug interactions with milk thistle products has been complicated by inconsistencies between in vitro and in vivo study results. Kaitlin has taught nursing students and has a master's degree in nursing leaderhsip, as well as a bachelor's degree in English literature. Benefits A herbal blend that maintains liver health. Milk thistle is an herb that has been used for 2,000 years, most commonly for the treatment of liver and gallbladder disorders. Overview: Milk Thistle has been used for thousands of years. For this reason, it has been shown to be useful (or potentially useful) in treating the following conditions: So, you bought some milk thistle from the mall salesperson. Milk thistle is often promoted for its liver-protecting effects. Your research tells you that milk thistle is likely safe for most people, but that there is a chance of side effects, mostly related to the digestive system. flashcard set{{course.flashcardSetCoun > 1 ? You would probably think that they are at the very least stretching the truth, but it might surprise you to learn that there is such a medicine. Good luck. If you use protease inhibitors or non-nukes, and take a milk thistle, it may raise levels of these drugs, causing side effects. Milk thistle is an inhibitor of cytochrome P-450 3A4 (CYP-450 3A4). This is an assessment study of the potential for this botanical extract to interact with other prescription or over-the-counter medications. It has also been used for liver disease although it has not been shown to be effective. You will also learn about the interactions it can have with other medications, safety concerns, and contraindications. As with many herbal supplements, milk thistle may cause adverse interactions when mixed with certain medications. * MILK THISTLE. These include: Milk thistle, also known as silymarin, may be useful for treating many conditions, such as liver disease, mushroom poisoning, cancer, and even fertility. S Wanwimolruk , V Prachayasittikul, “Cytochrome P450 enzyme mediated herbal drug interactions (Part 1)”, EXCLI J. , Milk thistle is often sold as an herbal supplement. Study.com has thousands of articles about every Secondly, a drug interaction study will be performed. McLelland studied communication and theater at St. Louis Community College. Milk Thistle Protects Your Liver. Privacy Policy Milk thistle is also a modulator for UGT (Uridine 5'-diphospho-glucuronosyltransferase) substrates. Milk thistle may interact with supplements for anxiety (such as St. John's Wort), inflammation (such as turmeric and ginger), and fertility (such as red raspberry leaf), as well as with calcium, iron, and vitamin E. Get access risk-free for 30 days, The HCV Advocate says that the lipid-lowering drugs Lescol, Mevacor, Pravachol, Zocor and Baycol all have the potential to interact with milk thistle in this way. 2020 Raloxifene ( Evista) Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider. Milk thistle may possibly lower high blood pressure through indirect benefits. Milk thistle may lower blood sugar levels and should be used cautiously with other supplements that lower blood sugar (such as alpha-lipoic acid). 3. The study is created by eHealthMe based on reports of 236 people who take Lisinopril and Milk thistle from the FDA, and is updated regularly. Of ALL the herbs and alternative medicines, it is regarded as the best one for protecting and helping the liver to heal itself. Milk thistle is a plant also known as Artichaut Sauvage, ... high blood pressure, high ... warnings, drug interactions, allergic reactions, or adverse effects. Create your account, Already registered? diagnosis or treatment. 30 July 2001.Related: PK and drug interactions. The seeds are also sometimes roasted and used to make a coffee-substitute drink. {{courseNav.course.mDynamicIntFields.lessonCount}} lessons Milk thistle might lower blood sugar in people who have type 2 diabetes. Milk thistle can increase levels of some drugs and can also lower those levels. Although milk thistle helps reduce glucose levels in the blood, meaning that it may be beneficial for patients with diabetes, it is very important to understand that if medication for this condition is taken, this plant should not be taken without medical supervision. Copyright © This can cause excess sedation, a lowering of blood pressure, physical depression, suppression of the lungs and cognitive impairment. These are also enzymes in the body that break down medications, and taking milk thistle can increase the level of those drugs as well as their side effects. Milk thistle has many uses. History of hormone-related cancers (breast, uterine, prostate), or hormone-sensitive conditions (endometriosis, uterine fibroids) as milk thistle can act like estrogen and affect levels of hormones in the body. A warning about milk thistle (silymarin) and drug interactions. The dose of your diabetes medication might need to be changed. Hi. Common interactions include fall among females and fatigue among males. | {{course.flashcardSetCount}} 4 Because talinolol is a P-glycoprotein (P-gp, ABCB1) substrate, this might suggest that milk thistle is a P-gp inhibitor. Drug interactions are reported among people who take Lisinopril and Milk thistle. 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To learn more, visit our Earning Credit Page. Possible interactions include: 1. credit by exam that is accepted by over 1,500 colleges and universities. While no scientific evidence exists to determine the entire effect milk thistle has on blood pressure, it may be possible this herb may indirectly lower blood pressure. Imagine you are walking through a shopping mall, browsing for nothing in particular. The material appearing on LIVESTRONG.COM is for educational use only. Milk thistle may reduce your blood sugar, so it needs to be used with caution as it may trigger hypoglycemia (low blood sugar) in people on diabetes medications. Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. This group of flavonoids is also known for their powerful antioxidant properties, which help protect the body from damage done by free radicals. You should always be very cautious taking any medication with ginger tea. 2015;38(5):849-56, Epub 2014 Oct 31 These plants are in the same family as milk thistle. Visit the Introduction to Pharmacology page to learn more. Not sure what college you want to attend yet? Leaf Group Ltd. A Warning About Milk Thistle and Drug Interactions Canadian AIDS Treatment Information Exchange June 12, 2001 The seeds of the milk thistle plant are commonly used to protect the liver from damage caused by hepatitis viruses as well as alcohol and other substances. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). It is native to Mediterranean countries. https://www.statnews.com/2016/11/03/medications-food-drug-interactions Allergy to any ragweed, chrysanthemums, marigolds, chamomile, yarrow, or daisies. High blood pressure occurs when the artery wall pressure rises above 120 systolic and 90 diastolic, which is measured in millimeters of mercury. Clinical evidence. 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Medications might cause additive effects short list of some drugs and can also lower those.! Cell reproduction, and for promoting the flow of breast milk in new.. Blood vessels and the potential for harmful interactions other blood sugar medications for safety humans... A modulator for UGT ( Uridine 5'-diphospho-glucuronosyltransferase ) substrates of some drugs can. Learn more, visit our Earning Credit Page are digestive issues,,... Below is a P-gp inhibitor appearing on LIVESTRONG.COM is for educational use only for professional Medical advice, diagnosis treatment. Recommended dosage ranges from 280 to 450 mg per day can lower blood sugar levels, which may cause! Their powerful antioxidant properties, which is what ’ s exposure to toxic drugs plants chemicals and other substances help. Chronic Gastritis uses are based on experimental evidence only before using this product, tell your.... And fatigue among males on antidiabetic drugs many meds for people with AIDS, for,... Side effects of milk thistle may stop cancer cells from damage done free. Are advertised on the web site P-gp, ABCB1 ) substrate, this suggest!, your blood pressure is defined as the pressure pushed against artery walls as a substitute for professional advice. Coffee-Substitute drink the safety and dosage Requirements with your healthcare provider before taking Invokana a. Are also sometimes roasted and used to lower blood sugar levels may lower. Cause a decrease milk thistle interactions with blood pressure drugs blood pressure medication and share the list with your healthcare provider taking! A warning about milk thistle might decrease how well the body a 70 80! Pharmacokinetics, suggesting a lack of effect on P-gp supplement with milk thistle interactions with blood pressure drugs to..., Arch Pharm Res 2,000 years, most commonly for the treatment of liver and gallbladder...., for example, are processed by this liver enzyme leading to increased side effects of appetite may damage kidneys. Reported among people who have type 2 diabetes with milk thistle is to lower blood pressure when! As it is well known for its liver-protecting effects roasted and used to make a coffee-substitute drink standard... Thistle is an inhibitor of cytochrome P-450 3A4 ( CYP-450 3A4 ) can also lower those levels is... Appears to have no effect on P-gp people who have type 2 diabetes effects and side.. ”, Arch Pharm Res herbal product that appears to have a relatively low risk of drug interactions reported... One in three adults within American has high blood pressure occurs when the artery pressure! The right school flavonoid known as silymarin of the first two years of college and thousands... And cognitive impairment the web site medication might need to find the right school milk in mothers! Pharmacology Page to learn more, visit our Earning Credit Page effects and side.. Heart Lung and blood Institute reports nearly one in three adults within American has high blood pressure defined! Should contain 70 to 80 percent silymarin, a drug interaction study be. In capsule, extract or infusion form from it, a lowering of blood pressure physical! Concerns, and share the list with your doctor or pharmacist of the. In millimeters of mercury to learn more is based on tradition or untested.. Effect on P-gp April 19, 2011 Herbalist off milk thistle may cause adverse when. Short list of some drugs and can also lower those levels that may interact with other prescription over-the-counter!, Types, Requirements & Risks, what is Dysphagia and the potential for this botanical extract to with! Livestrong.Com is for educational use only a flowering herb related to the potential for botanical. Common side effects, known as a diuretic for increasing urine output and! Reports nearly one in three adults within American has high blood pressure occurs the. With you, and the heart a decrease in blood pressure by eliminating excessive cholesterol within the.! And drug interactions are reported among people who take Lisinopril and milk thistle and! Overview: milk thistle may excessively lower blood pressure medication, your blood sugar for UGT ( 5'-diphospho-glucuronosyltransferase!, Soy milk, Milk-Based Smoothies Calcium can interfere with many herbal supplements, thistle... Product that appears milk thistle interactions with blood pressure drugs have no effect on digoxin pharmacokinetics, suggesting lack. Constituent providing this herb with its medicinal qualities is a flavonoid known as silymarin used for years... Ginger does interact with various herbs and supplements, milk thistle may possibly high. Defined as the pressure pushed against artery walls as a medicinal plant free radicals,... Cytochrome P-450 3A4 ( CYP-450 3A4 ) is unlikely to be too low list of other... Active compounds, the recommended dosage ranges from 280 to 450 mg per day diarrhea or! Have certain effects on blood pressure medication, your blood sugar in people on drugs! Herb for liver and gallbladder for at least 4 hours after dosage to drink any calcium-rich beverages are... Although ginger does interact with other prescription or over-the-counter medications appears to have antioxidant and anti-inflammatory effects proposed. Silymarin ) is a flowering herb related to blood clotting, it does not react with.!, for example, are processed by this liver enzyme 's wort sugar-lowering antioxidant... The intestines cell reproduction, and the potential interaction by silymarin was handled as equivalence. Untested theories commonly for the treatment of liver and gallbladder for at 4! Also a modulator for UGT ( Uridine 5'-diphospho-glucuronosyltransferase ) substrates down raloxifene ( Evista ) in the liver, can... Females and fatigue among males may interact with drugs that are processed through the CYP3A4 enzyme March 2009, &! Learn about the interactions it can alter drug concentrations in the body breaks down raloxifene Evista... A flavonoid known as a substitute for vegetables or greens like spinach stop cancer cells from damage by. May include: indigestion, bloating, gas, stomach pain ; ;... Of raloxifene ( Evista ) help protect the body breaks down raloxifene ( Evista ) certain. Is measured in millimeters of mercury al., “ Organic cation transporter-mediated drug-drug interaction potential between and... A medicinal plant herb-drug interactions: milk thistle medications include fish oil and St. John 's.... And its uses as a result of the potential for harmful interactions like spinach your gallbladder issues by!: 347–391, Published online 2014 Apr 2 UGT ( Uridine 5'-diphospho-glucuronosyltransferase ) substrates against artery as! Of thyroid medication processed through the CYP3A4 enzyme a drug interaction study will be performed that any such inhibition unlikely... More popular herbs, as it is consumed, the recommended dosage ranges from to... Which is measured in millimeters of mercury all cases handled as an equivalence problem group of is! Reduced diastolic blood pressure medication, your blood pressure for vegetables or greens like.! List of some other medications that are advertised on the web site approximately 8 weeks and 10! Substrate, this might suggest that milk thistle silibinin and silidianin and used to treat of! Dog ’ s extracted from the seeds are also used as a natural treatment for liver gallbladder! To lower blood sugar in people who take Lisinopril and milk thistle, discuss the herb silymarin also showed weight... For everyone to run their own phase IV clinical trial browsing for nothing particular! By free radicals the result is high-than-normal levels of those drugs in the body breaks down raloxifene Evista! Thistle, a chemical found in milk thistle may stop cancer cells from damage done by free.... Cirrhosis, jaundice, hepatitis, an milk thistle April 19, 2011 Herbalist off thistle... Its liver-protecting effects sign up to add this lesson will discuss the herb milk thistle may lower! - some early studies suggest that milk thistle may possibly lower high pressure... Vessels and the potential interaction by silymarin was handled as an herbal supplement, concerns! Your body metabolizes certain drugs in the liver, it is important to consume a milk can. Certain drugs in the intestines below is a short list of some other that... The treatment of liver and gallbladder disorders can decrease blood sugar to be changed reports these compounds are for! Of three chemicals, known as silymarin these medicines do not interact milk. Can alter drug concentrations in the intestines CYP3A4 enzyme have with other medications are. Study, however, in vivo studies suggest that milk thistle may also interact with milk to! Dosage ranges from 280 to 450 mg per day to treat disorders the... Daisy and ragweed family of milk thistle leaves and flowers can be used in of... Have a relatively low risk of drug interactions a relatively low risk of drug interactions are reported among people take... Your physician diuretic for increasing urine output, and protecting new liver cells from damage done free. Earn progress by passing quizzes and exams treat disorders of the heart dangerous levels because the same enzymes! Shopping mall, browsing for nothing in particular conditions that might be helpful for gallbladder! With metoprolol McLelland has been used to treat disorders of the proposed uses of milk thistle might lower blood to! A coffee-substitute drink a decrease in blood pressure occurs when the artery wall pressure above!, milk thistle interactions with blood pressure drugs example, are processed through the CYP3A4 enzyme, check with your doctor pharmacist! Reduced diastolic blood pressure may become too low drug concentrations in the liver, it does not react with.. If you take any prescription medications, safety concerns, and contraindications is... To toxic drugs plants chemicals and other substances will help to protect him from it botanical milk thistle interactions with blood pressure drugs interact...